Leopard Gecko Skin Tumors Traced to Cancer Gene - Howard Hughes Medical Institute
Lemon Frost leopard geckos are known for their distinctive coloring – and skin tumors. Scientists have now linked the tumors to a gene implicated in human skin cancer. Credit: L. Guo et al./ PLOS Genetics 2021/Steve Sykes The leopard gecko's name was Mr. Frosty, and he was hard to miss. Yellow bands striped his back, and uncommonly white skin peeked out from speckles on his head and tail. "It's this really striking coloration pattern," says Howard Hughes Medical Institute Investigator Leonid Kruglyak, a geneticist at the University of California, Los Angeles (UCLA). A California reptile shop began breeding Mr. Frosty in 2016 and produced a colony of lemon-yellow lizards. The color variety was known as Lemon Frost. With their bold bands and snazzy spots, the rare animals could fetch upwards of $2,000. But the gaudy geckos had one problem. Roughly 80 percent develop bulbous white skin tumors within the first five years of life. In some in...